Gabapentin Enacarbil: Pharmacotherapy of Restless Legs Syndrome
نویسندگان
چکیده
منابع مشابه
Gabapentin Enacarbil: Pharmacotherapy of Restless Legs Syndrome
Restless Legs Syndrome (RLS) is a prevalent sleep-associated movement disorder greatly affecting patients' quality of life (QoL). Several drugs can be used to control this condition although the first-line dopamine agents often cause adverse effects. Non-dopaminergic drugs such as oral gabapentin (GBP) have been more recently advocated. Despite ameliorating RLS symptoms, GBP's pharmacokinetic l...
متن کاملRole of gabapentin enacarbil XR in restless legs syndrome
Gabapentin enacarbil XR is a new extended-release formulation which attempts to overcome the reduced efficacy of shorter-acting gabapentin, with sustained delivery over a 24-hour period. It is a gabapentin prodrug which is efficiently and rapidly converted to gabapentin during active transport throughout the length of the intestine via high-capacity monocarboxylate type 1 nutrient transporters ...
متن کاملGabapentin enacarbil – clinical efficacy in restless legs syndrome
Restless legs syndrome (RLS) is a sleep-related movement disorder commonly involving an unpleasant urge to move the limbs, typically the legs. Dopaminergic agents represent the first-line therapy for RLS; however, long-term use of such drugs results in worsening symptoms due to "augmentation" or other adverse events. Gabapentin, an analog of the inhibitory neurotransmitter gamma-aminobutyric ac...
متن کاملReview of the Treatment of Restless Legs Syndrome: Focus on Gabapentin Enacarbil
The FDA approved gabapentin enacarbil in 2011 as the first non-dopaminergic agent for the treatment of restless legs syndrome (RLS) symptoms. Although gabapentin enacarbil is a pro-drug of gabapentin, its pharmacokinetics differ. Absorption of gabapentin enacarbil is more predictable, and inter-patient variability in bioavailability is lower than that of gabapentin. Studies have demonstrated su...
متن کاملPharmacotherapy Options in Restless Legs Syndrome
Restless legs syndrome (RLS) is a common sleep disorder, clinically diagnosed in the presence of a unique symptom complex which adversely impacts a patient’s quality of life. There is an urge to move the legs which develops during or is worsened by rest, is alleviated with movement, and is more severe in the evenings. RLS can be idiopathic or exist in association with several conditions includi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Central Nervous System Disease
سال: 2010
ISSN: 1179-5735,1179-5735
DOI: 10.4137/jcnsd.s4886